Shah said she commonly has to advise patients to take multivitamins or protein supplements in addition to the medication because they aren't getting the nutrients they need from food. Though it is not mentioned on Ozempic's website, doctors have reported some patients, their appetites so suppressed, experience malnutrition. The most severe complications Shah sees in her patients are pancreatitis and gallbladder issues - either can lead to hospitalization. Other serious side effects of Ozempic include thyroid tumors, pancreatitis, changes in vision, hypoglycemia, gallbladder issues, kidney failure and cancer. Because the brain and gut are so connected, the emotional symptoms can in turn worsen the gastrointestinal symptoms creating a vicious cycle," she said. "Anxiety about when and where symptoms will occur can also lead to avoidance of social activities, especially ones in which food is the focus, or when bathrooms may not be readily available. Keefer said these symptoms can leave patients feeling isolated, overwhelmed and embarrassed. Keefer, an academic health psychologist and the Director for Psychobehavioral Research within the Division of Gastroenterology at Mount Sinai, told CBS News. "Chronic abdominal pain and unpredictable digestive symptoms such as nausea, diarrhea, fullness or constipation can take a significant toll on your mood and energy levels," Laurie A. The stomach and brain are so connected that intestinal issues can lead to stress, anxiety and depression - it's what's known as the " gut-brain connection." These side effects can sometimes get better over time but, Shah said, at least 10% of patients who start these drugs have to be taken off of them because the side effects do not improve.Ĭonstant nausea and abdominal pain is an unpleasant reality. Meera Shah, an endocrinologist at the Mayo Clinic, said that by far the most common side effect she sees in patients is nausea, followed by abdominal pain, constipation and diarrhea. The most common adverse reactions, as with all GLP-1s, are gastrointestinal related."ĭr. Novo Nordisk, the maker of Ozempic and Wegovy, told CBS News that the drugs "are a well-established class of medicines, which have demonstrated long-term safety in clinical trials.
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